Vitamin B12 ~ Treatment

Not as bad as it looks...

Not as bad as it looks...

Vitamin B12 is the first port of call for many doctors when faced with CFS/ME. It can be taken under the tongue (sublingual), by injection into the fat (subcutaneous) or muscle (intramuscular). There are 3 types of B12 from which to choose, including: Hydroxocobalamin, Cyanocobalamin and Methylcobalamin.


The basic idea is that despite having Vitamin B12 in the body it is not crossing the brain/blood barrier.

My experience: (27/1/10) Based on nearly universal use of B12 in CFS/ME treatment I decided to learn how to inject myself and have begun injecting 1ml of Hydroxocobalamin into my stomach fat twice a week. Its to early to give definitive feedback but I noticed cognitive improvements almost immeadiately .

(16/3/10) I have slowly been increasing the frequency of 1ml injections up to every second or third day and continue to reap the benefits of increased cognitive abilities, a clear head and general rise in energy. Its fantastic. It is slow release due to the injection method. Will keep on this until there is no more benefit.

(31/8/10) I continue to get benefits from injecting each day. I have increased the dose to about 2mls a day and now use a more concentrated version which means less liquid and more B12. I use it before work, meetings or intense games of Connect Four.

The jab’s are always fun. You get to feel like a mad scientist when you squirt red liquid out of the top of the syringe. It’s easy and painless but still a little character building.

Links/More information:

Dr Sarah Myhills site gives a great run down on the use of B12 in CFS/ME here.

The website Chronic Fatigue Treatments has an interesting article with Dr. Martin Pall covering the use of B12 injections here.

Where to next? Techniques ~ Starting a Yoga practice that will give you back your mornings.

8 Responses to Vitamin B12 ~ Treatment
  1. […] to Next? – Read about Vitamin B12 the most popular treatment out there 1 Comment – Leave a comment! « Previous Post Next Post » […]

  2. Vitamin B12
    December 5, 2010 | 7:21 am

    Vitamin B12 injections are obviously the best form, as the B12 is absorbed fairly quickly. For others, such as the elderly, who have problems absorbing B12 via the stomach, then sublingual B12 or b12 patches are a great alternative.

  3. Renee K
    July 7, 2012 | 1:10 am

    Do you still continue your B12 injections? If so, how much & how often?

    I’ve been self-injecting 1ml of cyanocobalamin 3 times a week for around 3 months now and I do notice some improvement in my energy levels, but nowhere near where I’d like to be. It’s killing me not having the stamina to keep up with all the things that my brain is telling my body I should be doing! After asking my MD, she’s agreed to let me try higher doses for a month, but she’s sending me a new script (I’m guessing because it will be Methyl or Hydro?).

    • Joe
      July 22, 2012 | 2:01 pm

      Hey Renee,
      Great to hear from you :)
      Glad to hear you’ve been getting some benefit from the B12 and you’ve got a MD willing to explore it with you.
      I know exactly what you mean about your brain wishing to out run your body after a dose, you have to be careful not to over do it. When I had the discipline I always found it very enjoyable to have an injection and then instead of rushing around like a headless chicken, just lying back in a comfortable chair and letting my brain feel the deep peace and relaxation that was accessible.

      I’m overseas at the moment so am not injecting the Hydroxycobalamin 2-3 times a week (5-8mls) at present. I have though just ordered some sub-lingual B12 from Protaceuticals in Holland and will be trialling those shortly.

      Good luck trialling your new script! Hope the ampules of red ambrosia leave you feeling as high as I did.

  4. will glavan
    November 20, 2013 | 1:35 pm

    When I was first diagnosed with CFS 4 years ago the clinic prescribed intramuscular (IM) injections of b12. these, after 6-8 weeks use, seemed to provide some benefit and i slowly regained some lost stamina. (but never got anything like back to normal).

    Subsequently I had difficulties maintaining the prescription regime and, after a long lapse of no injections (and noticeable decline) I began doing subcutaneous injections. although these are of much greater frequency and therefore dose than the intramuscular had been, after 3 months I am realising virtually no change, no benefit.

    I switched back to IM for a bit, but for some reason these are now very painful — but why? the only variable is that i am now injection methyl- rather than cyno- cobalamine. Could this be causing pain?

    as as aside: I am also now injecting magnesium. Intolerable via IM and quite painful SubQ.

    1/ Is there any medical reason why intramuscular injections would produce better results that subcutaneous, even if the latter are administered with much higher frequency and dosage?

    2/ Is there any reason for mythyl b12 to be significantly more painful vs cyno b12?

    • Joe
      February 7, 2014 | 9:40 am

      Hey Will good to hear from you. I’m not an expert on this so hopefully someone with more knowledge can chip in and give an answer.

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  6. John Silver
    August 22, 2016 | 4:48 pm

    I find combining B12 + B-complex shots give me more and “complete” energy rather than just B12. My B12 is Cyno* 2mg. B-complex shot has about 100mcg (approx) of each of the B vitamins PER ML. I take 2ml of the B-complex shot.

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Welcome! I'm Joe and my vision is to empower people with the knowledge they need to take control of their health. I was diagnosed with Chronic Fatigue Syndrome (CFS/ME) in 2003 and recently added Lyme disease to that diagnosis in 2012. I'm on a path to recovery and I invite you to join me..... P.S. It's best to never take anything I say too seriously. In fact I reckon it's best to never take anything too seriously!